The search for new antiparasitic agents. 14. the synthesis, acute toxicity and anthelmintic activity of N- (3,5-dibromobenzo-2,1,3-thiadiazolyl-4) -2-[ (4-ch lorophenylsulfonyl) amino]-5-bromobenzamide
Mikhaĭlitsyn, F.S.; Kozyreva, N.P.; Veretennikova, N.L.; Lebedeva, M.N.; Pereverzeva, E.V.; Lychko, N.D.
Meditsinskaia Parazitologiia i Parazitarnye Bolezni 2: 30-32
1995
ISSN/ISBN: 0025-8326 PMID: 8596507 Document Number: 7896
The synthesis of 3 sulfonamidobenzamides containing a benzo-2,1,3-thiadiazole residue in the benzamide group is described. Compounds I, II and III were tested against Trichinella in mice 25-30 days after infection. Compound III, N-(3,5-dibromobenzo-2,1,3-thiadiazolyl-4)-2-((4-chlorophenylsulfonyl)amino)-5-brombenzamide, at a single dose of 0.1 g/kg bwt was found to be more effective than mebendazole whilst compounds I and II were ineffective.
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