Synthesis of substituted benzamides and benzimidazoles as anthelmintic and antimicrobial agents
Charles, E.S.; Rao, K.V.; Sharma, S.
Die Pharmazie 37(6): 413-415
1982
ISSN/ISBN: 0031-7144 PMID: 7122681 Document Number: 191500
The synthesis and biological activity of a series of substituted benzamides (5-8, 14-17) 3,5-dinitrobenzoic acids (12, 13, 18) and benzimidazoles (9-11, 19-21) are described. Compounds 5, 6, 7, 12 and 14 showed 40-50% clearance of Nippostrongylus brasiliensis in rats at a dose of 250 mg/kg given daily for 3 d while a few compounds inhibited the growth of various strains of bacteria and fungi.
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