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Synthesis of novel 1,3,4-oxadiazole derivatives as potential antimicrobial agents

Chawla, R.; Arora, A.; Parameswaran, M.K.; Chan, P.; Sharma, D.; Michael, S.; Ravi, T.K.

Acta Poloniae Pharmaceutica 67(3): 247-253

2010

ISSN/ISBN: 0001-6837
PMID: 20524426
Document Number: 644767
Some new 3-acetyl-5-(3-chloro-1-benzothiophen-2-yl)-5-substituted phenyl-1,3,4-oxadiazoles (5a-h). The structures of newly synthesized compounds (4a-h) and (5a-h) have been confirmed by spectroscopic techniques such as IR, 1H NMR and elemental analysis. All the compounds were screened for their antibacterial activities against Staphylococcus aureus, Bacillus subtilis. Escherichia coli and Pseudomonas aeruginosa and for antifungal activity against Candida albicans and Asperigillus niger. The compounds exhibited significant antibacterial and moderate antifungal activities. Compounds 4c and 4e were found to be most potent with activities, even better than standard drug ciprofloxacin against S. aureus and B. subtilis.

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