Synthesis, antibacterial, antifungal and genotoxic activity of bis-1,3,4-oxadiazole derivatives
Maslat, A.O.; Abussaud, M.; Tashtoush, H.; Al-Talib, M.
Polish Journal of Pharmacology 54(1): 55-59
2002
ISSN/ISBN: 1230-6002 PMID: 12020044 Document Number: 546932
In the present investigation, four 1,3,4-bis-oxadiazole derivatives were synthesized as potential antimicrobial agents. The compounds are: 5,5'-dimercapto-bis-(1,3,4-oxadiazol-2-yl)propane (2a), 5,5'-dimercapto-bis-(1,3,4-oxadiazol-2-yl)butane (2b), 5,5'-dimercapto-bis-(1,3,4-oxadiazol-2-yl)octane (2c) and 5,5'-dibenzylthio-bis-(1,3,4-oxadiazol-2-yl)butane (3). The above newly synthesized compounds were investigated for their antibacterial, antifungal and mutagenic activities. The results of the biological activities revealed that the compounds 2a-c exhibited both antibacterial and antifungal activities against S. aureuss and B. subtilis. Compound 2a also showed activity against P. aeureoginosa. All the above compounds and compound 3 exhibited activity against C. albicans. Genotoxic studies showed that compound 2a had a weak base pair substitution mutagenicity but none of them exhibited a frameshift mutagenic action using Ames test.