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Synthesis of derivatives of (9S) -9-hydroxyl-12-methylene erythromycin A and their antibacterial activity in vitro

Xu, P.; Yang, Y.; Shi, Y.; Lei, P-Sheng.; Liu, L.

Yao Xue Xue Bao 42(5): 497-501

2007

ISSN/ISBN: 0513-4870
PMID: 17703771
Document Number: 612561
The derivatives of (9S)-9-hydroxyl-12-methylene erythromycin A were synthesized by using erythromycin A as a starting material. An intermediate (9S)-9, 11-O-isopropylidene-6-0-allyl-2', 4 ''-0-bis (benzoyl)-12, 21-anhydro erythromycin A 12 was obtained. The antibacterial activity in vitro of two compounds, 6 and 11, was tested. The preliminary biological test showed that two compounds exhibited less potent antibacterial activity in vitro.

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