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Antibacterial and antifungal compounds. VIII. Synthesis and antifungal activity of pyrrol derivatives similar to trichostatin a

Corelli, F.; Massa, S.; Stefancich, G.; Mai, A.; Artico, M.; Panico, S.; Simonetti, N.

Il Farmaco; Edizione Scientifica 42(12): 893-903

1987

ISSN/ISBN: 0430-0920
PMID: 3329612
Document Number: 297207
Some p-methylbenzolpyrrole acrylic acids and related compounds were synthesized. The new pyrrole derivatives have structural features in common with trichostatin A, an antifungal antibiotic. The above acids and derivatives were tested against Candida albicans and Candida sp in comparison with miconazole, pyrrolnitrin and amphotericin B and showed very weak antifungal activities. Occasionally some activity was found against a few strains of Candida albicans and against Candida pseudotropicalis.

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