Antifungal agents. 10. Synthesis and antifungal activities of aryl- (1H-imidazol-1-yl) - (isoquinolin-1-yl) methane derivatives
Silvestri, R.; Pagnozzi, E.; Troccoli, F.; Stefancich, G.; Massa, S.; Apuzzo, G.; Perazzi, M.E.; Artico, M.; Simonetti, G.
Farmaco 50(4): 227-238
1995
ISSN/ISBN: 0014-827X PMID: 7669167 Document Number: 442028
Various aryl-(1H-imidazol-1-yl)-(isoquinolin-1-yl)methane derivatives have been synthesized and tested as antifungal agents. The new imidazoles have been obtained by the action of 1,1'-sulfinyldiimidazole on aryl-(isoquinolin-1-yl)carbinols, which have been prepared by standard procedures starting from isoquinoline. Among 44 test derivatives only a few have exhibited some antifungal activity, the most active compound (4e) being twofold less potent than miconazole, ketoconazole and bifonazole, used as standard drugs.