Synthesis, characterization and evaluation of mannich bases as potent antifungal and hydrogen peroxide scavenging agents
Malhotra, M.; Sharma, R.; Sanduja, M.; Kumar, R.; Jain, J.; Deep, A.
Acta Poloniae Pharmaceutica 69(2): 355-361
2012
ISSN/ISBN: 0001-6837 PMID: 22568052 Document Number: 656480
In the present study, (E)-2-{ [-2-(2,4-Dinitrophenyl)hydrazono]methyl} phenol (3) was synthesized and used as key intermediate for the synthesis of new Mannich bases. All the synthesized compounds were evaluated for their antifungal activity against three fungal strains Candida albicans, Candida tropicalis and Aspergillus niger and antioxidant activity. The structure of these compounds was confirmed by IR, 1H NMR and 13C NMR studies. Most of the compounds exhibited moderate to significant activities.