Synthesis of quinoline-Mannich bases of possible antimalarial activity
Kamel, M.M.; Nabih, I.; Nasr, M.E.; Abbasi, M.M.
Die Pharmazie 40(9): 622-623
1985
ISSN/ISBN: 0031-7144 PMID: 3906678 Document Number: 255819
For possible antimalarial activity, a series of some 4-substituted aminoquinoline Mannich bases (5a-e) was synthesized. The antimalarial evaluation showed that compound 5b was active against Plasmodium berghei in mice at a dose of 100 mg/kg.
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