Synthesis of purine bases having a di (hydroxymethyl) cyclopentenyl group by means of high-pressure reaction and their anti-HIV activity
Katagiri, N.; Nomura, M.; Sato, H.; Tameda, C.; Kurimoto, A.; Arai, S.; Toyota, A.; Kaneko, C.
Nucleic Acids Symposium Series 25: 5-6
1991
ISSN/ISBN: 0261-3166 PMID: 1842092 Document Number: 368016
The 1'- and 5'-hydroxymethyl derivatives of carbovir and related purine derivatives were synthesized from 5-hydroxymethylcyclopentadiene. The anti-HIV activity evaluation of these compounds has revealed that 9-(c-4,t-5-dihydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine is a prospective chemotherapeutic agent against AIDS.
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