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Synthesis and biological activity of new heterocyclic structures: [1,3]thiazino[2,3-i]purine, thiazolo[3,2-c] [1,2,3]triazolo[4,5-e]pyrimidine and [1,2,3]triazolo [4', 5': 4,5] pyrimido[6,1-b][1,3]thiazine

Rinaldi, M.; Pecorari, P.; Costantino, L.; Provvisionato, A.; Malagoli, M.; Cermelli, C.

Farmaco 47(10): 1315-1322

1992

ISSN/ISBN: 0014-827X
PMID: 1482518
Document Number: 404334
Some derivatives of thiazolo[3,2-c]pyrimidine, pyrimido[6,1-b][1,3]thiazine, thiazolo[2,3-i]purine, [1,3]thiazino[2,3-i]purine, thiazolo[3,2-c][1,2,3]triazolo[4,5-e]pyrimidine and [1,2,3]triazolo[4',5':4,5]pyrimido[6,1-b][1,3]thiazine were prepared. The compounds were tested for antimicrobial and antimycotic activity on a number of strains, namely, Escherichia coli, Proteus vulgaris, P. mirabilis, Pseudomonas aeruginosa, Salmonella sp., Staphylococcus aureus, Streptococcus faecalis, Bacillus subtilis, Sarcina lutea, Candida albicans, Aspergillus sp., and for antiviral activity on Herpes simplex virus, Type 1 (HSV-1), Vesicular stomatitis virus (VSV) and Coxsackievirus B5 (CoxB5). The compounds proved to be devoid of activity against viruses, mycetes and gram-negative bacteria, while some of them exhibited a modest activity against gram-positive bacterial strains.

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Sayed, H.H.; Shamroukh, A.H.; Rashad, A.E. 2006: Synthesis and biological evaluation of some pyrimidine, pyrimido[2,1-b][1,3]thiazine and thiazolo[3,2-a]pyrimidine derivatives Acta Pharmaceutica 56(2): 231-244
Baraldi, P.G.; Cacciari, B.; Spalluto, G.; Pineda de las Infants, M.J.; Zocchi, C.; Ferrara, S.; Dionisotti, S.; FerraDDionisotti, S. 1996: 1,2,3-Triazolo[5,4-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: a new class of A2A adenosine receptor antagonists Farmaco 51(4): 297-300
Kandeel, E.M.; Hammouda, M.; Metwally, M.A. 1996: Aminoazoles in heterocyclic synthesis. Synthesis of some new pyrimidobenzimidazoles and pyrazolonopyridines as well as triazolo-, tetrazolo- and pyrazolo-pyrimidines of pharmaceutical interest Bollettino Chimico Farmaceutico 135(4): 232-235
Delgado, F.; Pastor, J.; García-Navío, J.L.; Vaquero, J.J.; Alvarez-Builla, J.; Sunkel, C.; de Casa-Juana, M.F.; Priego, J.G.; Santos, L.R.; Statkow, P.R.; Straumann, D. 1997: Nonpeptide angiotensin Ii receptor antagonists: synthesis and biological activity of 1H-imidazo and 1H-[1,2,3]-triazolo fused derivatives Farmaco 52(3): 147-155
Ali, K.A.; Ragab, E.A.; Farghaly, T.A.; Abdalla, M.M. 2011: Synthesis of new functionalized 3-substituted [1,2,4]triazolo [4,3-a]pyrimidine derivatives: potential antihypertensive agents Acta Poloniae Pharmaceutica 68(2): 237-247
Holla, B.S.; Shivananda, M.K.; Akberali, P.M.; Baliga, S.; Safeer, S. 1996: Studies on arylfuran derivatives-Part VI. Synthesis, characterization and antibacterial activities of some 6-(5-aryl-2-furyl)-1,2,4-triazolo [3,4-b]-1,3,4-thiadiazoles and 6-(5-nitro-2-furyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles Farmaco 51(12): 785-792
Mazzone, G.; Bonina, F.; Pignatello, R.; Panico, A.M.; Caruso, A.; Leone, M.G.; Amico-Roxas, M.; Blandino, G. 1989: Carboxymethyl- and carboxy-derivatives of 7H- and 5H-1,2,4-triazolo [3,4-b][1,3,4] thiadiazine: synthesis and biological evaluation Farmaco 44(10): 933-944
Schulz, U.; Freitag, M.; Schmidt, K.; Witetschek, M.; Polzin, M.; Morgenstern, O. 2014: Synthesis and structure elucidation of 2,3,5,6,7,8-hexahydro-1 H-[1,2,4]triazolo[1,2-a]pyridazine-1-thione, 3,3-disubstituted and 2-substituted derivatives and evaluation of their inhibitory activity against inducible nitric oxide synthase Die Pharmazie 69(10): 731-744
Passarotti, C.M.; Valenti, M.; Marini, M. 1995: In the search for new antiinflammatory drugs: synthesis and antiinflammatory activity of some Thiazolo(3,2-a)pyrimidine derivatives containing a thioether group Bollettino Chimico Farmaceutico 134(11): 639-643
Guryn, R.; Szadowska, A.; Kiełek, M.B. 1988: Synthesis and pharmacologic properties of s-triazolo-1,4-diazepine derivatives Acta Poloniae Pharmaceutica 45(6): 512-516
Tarzia, G.; Occelli, E.; Barone, D. 1988: Benzodiazepine receptor ligands. Synthesis and pharmacological evaluation of 6-aryl-3,8-disubstituted-1,2,4-triazolo[3,4-a]phthalazines Il Farmaco; Edizione Scientifica 43(11): 921-933
Malinka, W.; Sieklucka-Dziuba, M.; Rajtar-Cynke, G.; Gasior, M.; Kleinrok, Z. 1995: Synthesis and pharmacological study of some derivatives of pyrazolo[4,3-c]pyrido[3,2-c]-1,2-thiazine-5,5-dioxide, a novel heterocyclic ring system Farmaco 50(1): 29-35
Tarzia, G.; Occelli, E.; Corsico, N.; Gallico, L.; Luzzani, F.; Barone, D. 1989: Benzodiazepine receptor ligands. Synthesis and preliminary pharmacological evaluation of 2-aminoalkyl-8-chloro- and 2-aryl-1,2,4-triazolo[3,4-a]phthalazine-3(2H)-ones Farmaco 44(1): 17-28
Pluta, J.; Flendrich, M.; Cieplik, J. 1996: Synthesis and biological activity of some pyrimidine derivatives Bollettino Chimico Farmaceutico 135(8): 459-464
Di Braccio, M.; Roma, G.; Grossi, G.; Ghia, M.; Mattioli, F. 1997: 1,8-Naphthyridines. III. N,N-dialkyl-5-chloro[1,2,4]-triazolo[4,3-a][1,8]naphthyridine-6-carboxa mides with anti-inflammatory activity Farmaco 52(1): 49-53
Wolski, T. 1978: The choice of medium suitable for the reaction of thiol groups with halogen derivatives in the synthesis of some purine and pyrimidine compounds. I. Synthesis of azathioprine Polish Journal of Pharmacology and Pharmacy 30(4): 593-599
Habib, N.S.; el-Hawash, S.A. 1997: Synthesis and antimicrobial testing of thiazolinyl-, thiazolidinonyl-quinoxalines and 1,2,4-triazolo[4,3-a]quinoxalines Die Pharmazie 52(8): 594-598
Kertscher, H.P. 1997: PAF-antagonists with lipid structure. 6. Alkylpropandiol lipids with acyl- and ether- structures at the C-3 position and heterocyclic head groups; synthesis, characterization and structure-activity relationship Die Pharmazie 52(9): 672-675
Askani, U.; Neidlein, R.; Tauber, J. 1971: Synthesis of substituted thiazolo-(3.2.-d)-tetrazolylium and thiazolo-(2.3.-b)-thiazolylium salts Die Pharmazie 26(8): 463-465
Ambrogi, V.; Grandolini, G.; Perioli, L.; Giusti, L.; Lucacchini, A.; Martini, C. 1993: Studies on annelated 1,4-benzothiazines and 1,5-benzothiazepines. VII. Synthesis and inhibition of benzodiazepine receptor binding of some 4,5-dihydro-tetrazolo[5,1-d]-1,5-benzothiazepines and 5-phenyl-s-triazolo[3,4-d]-1,5-benzothiazepines Farmaco 48(5): 665-676