Studies on arylfuran derivatives-Part VI. Synthesis, characterization and antibacterial activities of some 6- (5-aryl-2-furyl) -1,2,4-triazolo [3,4-b]-1,3,4-thiadiazoles and 6- (5-nitro-2-furyl) -1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles
Holla, B.S.; Shivananda, M.K.; Akberali, P.M.; Baliga, S.; Safeer, S.
Farmaco 51(12): 785-792
1996
ISSN/ISBN: 0014-827X PMID: 9050211 Document Number: 463342
A series of 4-[5-aryl-2-furfurylidene]amino-3-mercapto-5-substituted-1,2,4-tri azoles and 4-[5-Nitro-2-furfurylidene]amino-3-mercapto-5-substituted-1,2,4-tr iazoles have been synthesized and were converted into 1,2,4-triazolo [3,4-b]-1,3,4-thiadiazoles. These triazolothiadiazoles are also synthesized by an alternative method in better yields employing arylfuroic acids and s-triazoles in the presence of phosphorus oxychloride. The newly synthesized compounds are screened for their antibacterial properties.