Carboxymethyl- and carboxy-derivatives of 7H- and 5H-1,2,4-triazolo [3,4-b][1,3,4] thiadiazine: synthesis and biological evaluation
Mazzone, G.; Bonina, F.; Pignatello, R.; Panico, A.M.; Caruso, A.; Leone, M.G.; Amico-Roxas, M.; Blandino, G.
Farmaco 44(10): 933-944
1989
ISSN/ISBN: 0014-827X PMID: 2619859 Document Number: 3845
Some carboxymethyl- and carboxy-derivatives of 7H- and 5H-1,2,4-triazolo [3,4-b][1,3,4] thiadiazine were prepared. Their structure are discussed on the basis of IR, NMR and mass spectra. The synthesized compounds were subjected to a preliminary pharmacological screening for antiinflammatory-analgesic activity and to microbiological test on various species of mycetes and bacteria.
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