Synthesis and biological evaluation of 1,2,5-oxadiazole N-oxide derivatives as hypoxia-selective cytotoxins
Monge, A.; López de Ceráin, A.; Ezpeleta, O.; Cerecetto, H.; Dias, E.; Di Maio, R.; González, M.; Onetto, S.; Seoane, G.; Suescun, L.; Mariezcurrena, R.
Die Pharmazie 53(11): 758-764
1998
ISSN/ISBN: 0031-7144 PMID: 9853357 Document Number: 487470
Synthesis and biological evaluation of new 1,2,5-oxadiazole N-oxide derivatives with potential cytotoxic effects are described. From the series of compounds tested, compounds 2 and 6 proved to be very active, although non-selective.
Document emailed within 1 workday
Related Documents
Pancechowska-Ksepko, D.; Foks, H.; Landowska, E.; Janowiec, M.; Zwolska-Kwiek, Z. 1986: Studies of pyrazine derivatives. XVII. Synthesis and the tuberculostatic activity of pyrazinyl-1,3,4-oxadiazole derivatives Acta Poloniae Pharmaceutica 43(2): 116-123Naylor, M.A.; Stephens, M.A.; Stratford, I.J.; Keohane, A.; O'Neill, P.; Threadgill, M.D.; Webb, P.; Fielden, E.M.; Adams, G.E. 1991: Aziridinyl nitropyrroles and nitropyrazoles as hypoxia-selective cytotoxins and radiosensitizers Anti-Cancer Drug Design 6(3): 151-167
Perrin, L.C.; Wilson, W.R.; Denny, W.A.; McFadyen, W.D. 1999: The design of cobalt(III) complexes of phenazine-1-carboxamides as prointercalators and potential hypoxia-selective cytotoxins Anti-Cancer Drug Design 14(3): 231-241
Chawla, R.; Arora, A.; Parameswaran, M.K.; Chan, P.; Sharma, D.; Michael, S.; Ravi, T.K. 2010: Synthesis of novel 1,3,4-oxadiazole derivatives as potential antimicrobial agents Acta Poloniae Pharmaceutica 67(3): 247-253
Maslat, A.O.; Abussaud, M.; Tashtoush, H.; Al-Talib, M. 2002: Synthesis, antibacterial, antifungal and genotoxic activity of bis-1,3,4-oxadiazole derivatives Polish Journal of Pharmacology 54(1): 55-59
Santagati, M.; Modica, M.; Santagati, A.; Russo, F.; Caruso, A.; Cutuli, V.; Di Pietro, E.; Amico-Roxas, M. 1994: Synthesis and pharmacological properties of benzothiazole, 1,3-4-oxadiazole and 1,3,4-thiadiazole derivatives Die Pharmazie 49(12): 880-884
Wang, H.; Wen, R.; Huang, L.; Bi, R.; Tan, P.Z. 2001: Synthesis and biological activities of new 5-HT2A selective ligands--N-substituted-piperidinyl-4-phenylthioether and sulfone derivatives Yao Xue Xue Bao 36(4): 274-277
Fang, F.; Chen, Y. 2015: Design, synthesis and biological evaluation of the novel trehalose derivatives Yao Xue Xue Bao 50(6): 725-732
Gong, Y.-X.; Zhu, Q.-F.; Zhong, J.-Q.; Liu, L.-F.; Li, X.-F.; Zheng, X.-H.; Luo, H.-Y.; Zhao, X.-Y. 2015: Design, synthesis and biological evaluation of novel [1,3] dioxolo [4,5-f]isoindolone derivatives Yao Xue Xue Bao 50(2): 191-198
Mazzone, G.; Bonina, F.; Pignatello, R.; Panico, A.M.; Caruso, A.; Leone, M.G.; Amico-Roxas, M.; Blandino, G. 1989: Carboxymethyl- and carboxy-derivatives of 7H- and 5H-1,2,4-triazolo [3,4-b][1,3,4] thiadiazine: synthesis and biological evaluation Farmaco 44(10): 933-944
Aftab, K.; Aslam, K.; Kousar, S.; Nadeem, M.J.U.H. 2016: Synthesis, characterization and biological evaluation of tryptamine based benzamide derivatives Pakistan Journal of Pharmaceutical Sciences 29(2): 423-428
Fang, Z.; Yang, Z.; Xu, J.-f.; Wang, Y.-l.; Wang, Z.-x.; Wei, P. 2011: Synthesis and biological evaluation of 3-aromatic Shiff base-5-fluoroindol-2-one derivatives Yao Xue Xue Bao 46(11): 1338-1343
Shen, Y.; Li, B.; Xu, H.; Zhang, G. 2013: Design, synthesis, and biological evaluation of acetophenone derivatives as dual binding acetylcholinesterase inhibitors Die Pharmazie 68(5): 307-310
Schulz, U.; Freitag, M.; Schmidt, K.; Witetschek, M.; Polzin, M.; Morgenstern, O. 2014: Synthesis and structure elucidation of 2,3,5,6,7,8-hexahydro-1 H-[1,2,4]triazolo[1,2-a]pyridazine-1-thione, 3,3-disubstituted and 2-substituted derivatives and evaluation of their inhibitory activity against inducible nitric oxide synthase Die Pharmazie 69(10): 731-744
Purkayastha, S.K.; Jha, T.; Pal, D.K.; De, A.U. 1993: Possible antineoplastic agents: Part XIII. Synthesis, biological evaluation and QSAR studies of some 1-(substituted benzenesulphonyl)-5-oxopyrrolidine-2-carboxylic acid derivatives Anti-Cancer Drug Design 8(2): 95-100
Sayed, H.H.; Shamroukh, A.H.; Rashad, A.E. 2006: Synthesis and biological evaluation of some pyrimidine, pyrimido[2,1-b][1,3]thiazine and thiazolo[3,2-a]pyrimidine derivatives Acta Pharmaceutica 56(2): 231-244
Huang, S-Tang.; Huang, W-Long.; Zhang, H-Bin. 2006: Synthesis and vascular relaxing activity of arecoline derivatives coupled with nitric oxide donors Yao Xue Xue Bao 41(1): 71-75
Pluta, J.; Flendrich, M.; Cieplik, J. 1996: Synthesis and biological activity of some pyrimidine derivatives Bollettino Chimico Farmaceutico 135(8): 459-464
Dorneanu, M.; Stefănescu, E.; Grosu, G. 1987: Synthesis of new pyridazine derivatives with biological activity Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 91(3): 541-543
Kornicka, A.; Hudson, A.L.; Bednarski, P.J. 2009: Synthesis and biological activity of some 2-imidazolinylhydrazone derivatives Acta Poloniae Pharmaceutica 66(5): 523-534