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Possible antineoplastic agents: Part XIII. Synthesis, biological evaluation and QSAR studies of some 1- (substituted benzenesulphonyl) -5-oxopyrrolidine-2-carboxylic acid derivatives

Purkayastha, S.K.; Jha, T.; Pal, D.K.; De, A.U.

Anti-Cancer Drug Design 8(2): 95-100

1993

ISSN/ISBN: 0266-9536
PMID: 8494605
Document Number: 417548
Twelve analogues of 1-(substituted benzenesulphonyl)-5-oxopyrrolidine-2- carboxylic acid have been synthesized and tested for antineoplastic activity in Swiss albino mice with an Ehrlich ascites carcinoma (EAC) cell line. The values of percent inhibition of growth, both in ascitic cell count and fluid weight, have been taken as activity parameters. Quantitative structure-activity relationships (QSAR) have been studied using the LFER model. The best correlation (R2 = 93.0%) was found using molar refractivity (MR), which measures the molar volume and polarizability of the substituents.

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Srikanth, K.; Kumar, C.A.; Goswami, D.; De, A.U.; Jha, T. 2001: Quantitative structure activity relationship (QSAR) studies of some substituted benzenesulphonyl glutamines as tumour suppressors Indian Journal of Biochemistry and Biophysics 38(1-2): 120-123
Guo, H.Y.; Sun, L.Y.; Tang, Y.; Yan, G.H.; Zhang, Z.P. 1988: Studies on pyridonecarboxylic acids as antibacterial agents. VI. Synthesis and antibacterial activity of 7-chloro-6-fluoro-1-ethyt-1, 4-dihydro-4-oxopyrido(2,3-c)pyridazine-3-carboxylic acid and derivatives Yao Xue Xue Bao 23(8): 566-573
El-Naggar, A.M.; Ahmed, F.S.; El-Salam, A.M.; El-Gazzar, M.A. 1982: Synthesis and biological activity of some new substituted aminoacyl-carbazole derivatives. Part Ii Il Farmaco; Edizione Scientifica 37(7): 494-500
Deep, A.; Kumar, P.; Narasimhan, B.; Lim, S.M.; Ramasamy, K.; Mishra, R.K.; Mani, V. 2016: Synthesis, Antimicrobial, Anticancer Evaluation and Qsar Studies of Thiazolidin-4-One Derivatives Acta Poloniae Pharmaceutica 73(1): 93-106
Shams el-Dine, S.A.; Soliman, F.S.; Ashour, F.A.; Saudi, M.N. 2001: Reactions with pyrrolidine-2,4-diones, Part 4: Synthesis of some 3-substituted 1,5-diphenylpyrrolidine-2,4-diones as potential antimicrobial, anti-HIV-1 and antineoplastic agents Die Pharmazie 56(12): 933-937
Brzezińska, E.; Stańczak, A.; Ochocki, Z. 2003: Structure and biological activity of some 4-amino-3-cinnolinecarboxylic acid derivatives. QSAR analysis of cinnoline derivatives with antibacterial properties Acta Poloniae Pharmaceutica 60(1): 15-20
Foks, H.; Janowiec, M.; Sienicka, J. 1976: Studies on pyrazine derivatives. Part V. Synthesis and tuberculostatic activity of some 6-(beta-aminoethoxy)-pyrazine-2-carboxylic acids Polish Journal of Pharmacology and Pharmacy 28(3): 295-300
Rao, D.V.; Rao, V.V.R.; Raghunanda, P. 1985: Studies on embelin part iii. synthesis and biological activity of some anthranilic acid ester derivatives of embelin and embelin di o methyl ether Indian Journal of Chemistry. Sect. B 24(9): 988-991
Kossakowski, J.; Krawiecka, M. 2000: Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XIII. Derivatives of 1-methoxybicyclo[2.2.2]oct-5-ene-2,3-dicarboximide Acta Poloniae Pharmaceutica 57 Suppl: 53-56
Meng, X.Y.; Zhang, X.P.; Li, B.S.; Li, G.D. 1989: Synthesis and antimalarial and antineoplastic activities of some derivatives of 2,4-diamino-5-methyl-6-substituted benzylaminoquinazolines Yao Xue Xue Bao 24(8): 578-586
Bahekar, S.S.; Shinde, D.B. 2003: Synthesis and anti-inflammatory activity of some [2-amino-6-(4-substituted aryl)-4-(4-substituted phenyl)-1,6-dihydropyrimidine-5-yl]-acetic acid derivatives Acta Pharmaceutica 53(3): 223-229
Machoń, Z.; Jasztold-Howorko, R. 1976: Synthesis of 2,4-disubstituted 5-aminopyrimidine-6-carboxylic acids derivatives part i Polish Journal of Pharmacology and Pharmacy 28(1): 61-67
Loriga, M.; Moro, P.; Sanna, P.; Paglietti, G.; Zanetti, S. 1997: Quinoxaline chemistry. Part 8. 2-[Anilino]-3-[carboxy]-6(7)-substituted quinoxalines as non classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity Farmaco 52(8-9): 531-537
Kaczmarek, L.; Nantka-Namirski, P. 1981: Cancerostatics. IV. on the synthesis of some noval 1-Azacarbazole derivatives as antineoplastic agents Polish Journal of Pharmacology and Pharmacy 33(1): 121-127
Milczarska, B.; Foks, H.; Sokołowska, J.; Janowiec, M.; Zwolska, Z.; Andrzejczyk, Z. 1999: Studies on pyrazine derivatives. XXXIII. Synthesis and tuberculostatic activity of 1-[1-(2-pyrazinyl)-ethyl]-4-N-substituted thiosemicarbazide derivatives Acta Poloniae Pharmaceutica 56(2): 121-126
Matosiuk, D.; Tkaczyński, T.; Jagiełło-Wójtowicz, E.; Zebrowska-Lupina, I.; Czuczwar, S.J.; Matuszek, B.; Klenk-Majewska, B.; Danilczuk, Z.; Janusz, W.; Kleinrok, Z. 1992: Synthesis and some central pharmacological properties of new derivatives of 2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylic acid Polish Journal of Pharmacology and Pharmacy 44(1): 67-78
Bukowski, L. 1980: Synthesis of imidazo [4,5-b] pyridine-7-carboxylic acid and some of its derivatives with expected antituberculous activity Polish Journal of Pharmacology and Pharmacy 32(5): 767-772
Ali, K.A.; Ragab, E.A.; Farghaly, T.A.; Abdalla, M.M. 2011: Synthesis of new functionalized 3-substituted [1,2,4]triazolo [4,3-a]pyrimidine derivatives: potential antihypertensive agents Acta Poloniae Pharmaceutica 68(2): 237-247
Yan, L.; Xu, B.; Ma, Z.; Zhu, Y.; Yang, Q. 1998: Synthesis and antibacterial activity of 7-substituted-1-ethyl(2-fluoro-ethyl)-6,8-difluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid Yao Xue Xue Bao 33(5): 392-395
Saczewski, F.; Foks, H.; Sawlewicz, J.; Szulc, K. 1986: Studies of benzimidazole derivatives. XIII. Synthesis of various 2-alpha-hydroxy- and 2-beta-hydroxyalkyl-benzimidazoles Acta Poloniae Pharmaceutica 43(4): 299-307