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Synthesis and some central pharmacological properties of new derivatives of 2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylic acid

Matosiuk, D.; Tkaczyński, T.; Jagiełło-Wójtowicz, E.; Zebrowska-Lupina, I.; Czuczwar, S.J.; Matuszek, B.; Klenk-Majewska, B.; Danilczuk, Z.; Janusz, W.; Kleinrok, Z.

Polish Journal of Pharmacology and Pharmacy 44(1): 67-78

1992

ISSN/ISBN: 0301-0244
PMID: 1437853
Document Number: 395421
Twenty one derivatives of 2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylic acid (6 n-butyl amides and 15 free acids) bearing the aromatic ring in position 1 or 2 were obtained. They were synthesized by aminolysis or hydrolysis of respective ethyl esters. Pharmacological studies on the central action of eight compounds 1, 2, 4, 5, 7, 8, 9 and 10 were carried out on mice and rats. The most active compounds, producing sedation and hypothermia, and 1, 2 and 5. The compounds decreased amphetamine-induced hyperactivity. Besides, compound 2 exerted analgesic effect in mice.

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