Synthesis and pharmacological screening of some N-carboxymethylbarbituric acid derivatives. i
Mirek, J.; Adamczyk, M.; Chojnacka-Wójcik, E.; Naparzewska, A.
Polish Journal of Pharmacology and Pharmacy 30(5): 685-693
1978
ISSN/ISBN: 0301-0244 PMID: 751009 Document Number: 133259
Reaction of haloacetate with barbital and methylphenobarbital in polar aprotic solvents in the presence of anhydrous K2CO3 gave N-carboalkoxymethyl derivatives in good yields. Acidic hydrolysis of the latter compounds affords N-carboxymethyl derivatives of barbital 8 or methylphenobarbital 7. From acid 7 and 8 via acid chlorides, amides 11--20 were prepared. These amides lack anticonvulsant activity and show only slight sedative and analgesic action.
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