Nicotinic and derivatives. VII. Synthesis of some derivatives of 2-anilino-5-hydroxynicotinic acid
Nantka-Namirski, P.; Rykowski, A.
Acta Poloniae Pharmaceutica 33(1): 7-11
1976
ISSN/ISBN: 0001-6837 PMID: 1266645 Document Number: 4377
2,5-Dihydroxypyridine has been found to be converted into 2-chloro-5-hydroxypyridine (IV) when subjected to action of phosphorus oxychloride. Analogically, 2-chloro-5-hydroxynicotinic acid (IIa) was obtained by chlorination of 2,5-dihydroxynicotinic acid. 2-Chloro-5-hydroxynicotinic acid was reacted with aniline hydrochloride or with its derivatives to yield respective 2-anilino-5-hydroxynicotinic acids. 3-Hydroxypyridy1(2,3-b)quimolin-(1OH)-5-one (VIIa) was resulted when 2-anilino-5-hydroxynicotinic acid (VIa) heated with polyphosphoric acid.
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