Photochemical synthesis of adenosine-8-phosphonic acid derivatives
Maruyama, T.; Adachi, Y.; Honjo, M.
Nucleic Acids Symposium Series 16: 117-120
1985
ISSN/ISBN: 0261-3166 PMID: 4088854 Document Number: 263831
Photochemical reaction of 2',3',5'-tri-O-acetyl-8-bromoadenosine (2) with triethyl phosphite, followed by deacetylation, gave diethyl adenosine-8-phosphonate (1). Intramolecular cyclization of diethyl 8-bromo-2',3'-O-isopropylideneadenosine-5'-phosphite (6) was accomplished with photo-irradiation to yield ethyl 2',3'-O-isopropylidene-adenosine-8,5'-phosphonate (4).
Document emailed within 1 workday
Related Documents
L'vov, N.D.; Samoĭlovich, E.O.; Tikhonchuk, I.A.; Chepaĭkina, T.A.; Tsvetkov, E.N. 1989: Antiherpetic activity of Soviet-made phosphonic acid derivatives and their combinations with interferon inducers in a model of ophthalmic herpes Voprosy Virusologii 34(2): 186-192Samoĭlovich, E.O.; L'vov, N.D.; Chepaĭkina, T.A.; Lidak, M.I.; Tsvetkov, E.N.; Bobkov, A.F.; Garaev, M.M.; Barinskiĭ, I.F. 1989: Effectiveness of Soviet derivatives of phosphonic acid and their combination with interferon inducers in cell cultures and in a model of herpetic meningoencephalitis in mice Voprosy Virusologii 34(4): 466-474
Pacuszka, T.; Panasiewicz, M.; Hoser, G.; Kawalec, M. 1998: Photochemical labeling of HL-60 cell membrane proteins with radioiodinated, 4-azidosalicylic acid acylated derivatives of gangliosides Acta Biochimica Polonica 45(2): 403-415
Nantka-Namirski, P.; Rykowski, A. 1976: Nicotinic and derivatives. VII. Synthesis of some derivatives of 2-anilino-5-hydroxynicotinic acid Acta Poloniae Pharmaceutica 33(1): 7-11
Woliński, J.; Ludwikow, M. 1971: Synthesis of some analogues of N,N-dimethylaminoethyl p-chlorophenoxyacetate hydrochloride. I. Derivatives of p-chlorophenoxyacetic acid and p-methoxyphenoxyacetic acid Acta Poloniae Pharmaceutica 28(3): 273-278
Nantka-Namirski, P.; Rykowski, A. 1972: Nicotinic acid derivatives. IV. Synthesis of 2,5-dihydroxy-6-methylnicotinic acid Acta Poloniae Pharmaceutica 29(3): 225-229
Wang, D.X.; Dai, C.L.; Zhao, C.; Qiu, M.C.; Tian, G.J.; Lin, H. 2001: Studies on the synthesis and bioactivity of alpha-alkylaminobenzyl-phosphonic acids Yao Xue Xue Bao 36(9): 657-659
Zirvi, K.A.; Jarboe, C.H. 1976: Synthesis and neuropharmacology of cyclobutanecarboxylic acid derivatives Il Farmaco; Edizione Scientifica 31(2): 152-158
Wei, X.D.; Cai, S.D.; Qiu, Y.G.; You, S.X. 1991: Effects of adenosine and its derivatives on cultured myocardial cells and detection of adenosine receptors in rat Zhongguo Yao Li Xue Bao 12(4): 316-319
Mirek, J.; Adamczyk, M.; Chojnacka-Wójcik, E.; Naparzewska, A. 1978: Synthesis and pharmacological screening of some N-carboxymethylbarbituric acid derivatives. i Polish Journal of Pharmacology and Pharmacy 30(5): 685-693
Machoń, Z.; Jasztold-Howorko, R. 1981: Synthesis and biological properties of some 5-aminoorotic acid derivatives Polish Journal of Pharmacology and Pharmacy 33(5): 545-552
Sun, K.L.; Li, R.S.; Lei, X.H. 1990: Studies on the synthesis and bioactivity of some new shikimic acid derivatives Yao Xue Xue Bao 25(1): 73-76
Kuemmerle, H.P.; Murakawa, T.; De Santis, F. 1987: Pharmacokinetic evaluation of fosmidomycin, a new phosphonic acid antibiotic Chemioterapia: International Journal of the Mediterranean Society of ChemoTherapy 6(2): 113-119
Meng, Y.-q.; Nie, H.-h.; Wang, X.-c.; Li, D.; Ge, C.-x.; Zhao, N.; Chen, H.; Cao, B. 2011: Synthesis and anti-tumor activity of oleanolic acid derivatives Yao Xue Xue Bao 46(10): 1215-1220
Erol, D.D.; Caliş, U.; Yuluğ, N. 1995: Synthesis and antimicrobial activities of some dithiocarbamate derivatives of Kojic acid Bollettino Chimico Farmaceutico 134(11): 620-623
el-Naggar, A.M.; Hussein, M.E.; el-Nemma, E.M.; Samour, A.A. 1985: Synthesis and antimicrobial activity of some new isonicotinoylamino acid and dipeptide derivatives Il Farmaco; Edizione Scientifica 40(9): 662-670
Meng, Y.-q.; Feng, C.-q.; Zhang, L.-f.; Zhang, M.; Zhao, N. 2015: Synthesis and anti-tumor activity of oleanolic acid derivatives Yao Xue Xue Bao 50(4): 469-474
Duro, F.; Condorelli, P.; Arrigo Reina, R. 1972: Synthesis and pharmacological activity of alkylamido-derivatives of 4-phenyl-3-isocoumarin acid Bollettino Chimico Farmaceutico 111(12): 740-748
Magdányi, L. 1973: Synthesis of 5,6-dimethoxy indazole-3-carbonic acid derivatives (preliminary study) Acta Pharmaceutica Hungarica 43(3): 142-146
Gezegen, H.; Karaman, I.; Ceylan, M.; Dilmaç, M. 2012: Synthesis and in vitro antimicrobial activity of novel 2-(3-oxo-1,3-diarylpropylthio)acetic acid derivatives Acta Poloniae Pharmaceutica 69(5): 893-900