Synthesis and in vitro antimicrobial activity of novel 2- (3-oxo-1,3-diarylpropylthio) acetic acid derivatives
Gezegen, H.; Karaman, I.; Ceylan, M.; Dilmaç, M.
Acta Poloniae Pharmaceutica 69(5): 893-900
2012
ISSN/ISBN: 0001-6837 PMID: 23061285 Document Number: 657326
A series of novel 2-(3-oxo-1,3-diarylpropylthio)acetic acid derivatives (3a-l) were prepared by base catalyzed addition of thioglycolic acid to chalcones (1a-l). The antibacterial activities of synthesized compounds were screened against human pathogenic microorganisms by employing the disk-diffusion technique. For the active compounds, also minimum inhibitory concentrations (MICs) were determined.