Synthesis and anti-inflammatory activity of some [2-amino-6- (4-substituted aryl) -4- (4-substituted phenyl) -1,6-dihydropyrimidine-5-yl]-acetic acid derivatives
Bahekar, S.S.; Shinde, D.B.
Acta Pharmaceutica 53(3): 223-229
2003
ISSN/ISBN: 1330-0075 PMID: 14769245 Document Number: 553106
Dihydropyrimidines 4a-r have been synthesized by base catalysed condensation of beta-aroylpropanoic acid, guanidine nitrate and aromatic aldehyde. Structures of the new compounds were established on the basis of 1H NMR and IR spectral data. Anti-inflammatory activity in vivo was evaluated and compared with standard drug diclofenac sodium.
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