Synthesis and pharmacological screening of some N,N'-bis-[4- (4-aryl-1-piperazinyl) butyl]-substituted derivatives of 1,8-dimethylbicyclo-[2.2.2]oct-7-ene-2,3,5,6-tetracarboxydiimide
Turło, J.; Zawadowski, T.; Rump, S.; Jakowicz, I.; Gidyńska, T.; Gałecka, E.
Polish Journal of Pharmacology 46(5): 451-455
1994
ISSN/ISBN: 1230-6002 PMID: 7894533 Document Number: 427567
The preparation of several derivatives of bicyclo[2.2.2]oct-7-ene- 2,3,5,6-tetracarboxydiimide on two routes has been described. Some of them display an expected anxiolytic activity. The 5-HT1A receptor affinities of tested compounds are comparable with that of buspirone.
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