Synthesis and pharmacological investigations of 3- (aminoalkylene) -1-aryl-2-thioxo-4,5-imidazolidinedione and 2,4,5-imidazolidinetrione derivatives
Zankowska-Jasińska, W.; Borowiec, H.; Golus, J.; Kolasa, A.; Zaleska, B.; Krzywosiński, L.; Bogdal, M.; Przemyk, B.
Polish Journal of Pharmacology and Pharmacy 42(1): 49-58
1990
ISSN/ISBN: 0301-0244 PMID: 2281020 Document Number: 366876
New derivatives of 2-thioxo-4,5-imidazolidinedione (3-6, 10, 11) and 2,4,5-imidazolidinetrione (7, 12) were synthesized by N,N'-acylation of asymmetric thioureas and ureas by oxalyl chloride. The obtained compounds were screened for their central action, mainly anticonvulsant activity.
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