Synthesis and pharmacological investigations of 3- (aminoalkylene) -1-aryl-2-thioxo-4,5-imidazolidinedione and 2,4,5-imidazolidinetrione derivatives

Zankowska-Jasińska, W.; Borowiec, H.; Golus, J.; Kolasa, A.; Zaleska, B.; Krzywosiński, L.; Bogdal, M.; Przemyk, B.

Polish Journal of Pharmacology and Pharmacy 42(1): 49-58


ISSN/ISBN: 0301-0244
PMID: 2281020
Document Number: 366876
New derivatives of 2-thioxo-4,5-imidazolidinedione (3-6, 10, 11) and 2,4,5-imidazolidinetrione (7, 12) were synthesized by N,N'-acylation of asymmetric thioureas and ureas by oxalyl chloride. The obtained compounds were screened for their central action, mainly anticonvulsant activity.

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