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Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8-bromobenzopyran derivatives

Ragab, F.A.E.-F.; Hassan, G.S.; Abu Yossef, H.A.-S.; Yahya, T.A.A.; Abd El-Latif, H.A.

Arzneimittel-Forschung 60(4): 171-176

2010

ISSN/ISBN: 0004-4172
PMID: 20486465
Document Number: 639678
Several thiosemicarbazones (7 and 8), 1,3-thiazolidin-4-ones (9, 10, 13, 14) and 2-thioxo-1,3-imidazolidin-4-ones (11) have been prepared starting from 8-bromo-7-hydroxy-5-methoxy-2-methyl-4-oxo-4H-1-benzopyran-6-carbaldehyde (3) and its 4-thio analogue (4). The anticonvulsant activity of all of the synthesized compounds was evaluated against maximal electrical shock (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizures. The neurotoxicity was assessed using the rota-rod test. Some of the tested compounds displayed potent anticonvulsant activity in the scPTZ test.

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Gürsu, E.; Ulusoy, N. 1990: Synthesis and anticonvulsant evaluation of new 1,3-disubstituted 2-thioxo-4,5-imidazolidinediones Die Pharmazie 45(10): 795-796
Calis, U.; Dalkara, S.; Ertan, M. 1992: Synthesis and anticonvulsant activity of some new 4-aryl-4-imidazoline-2-one derivatives Arzneimittel-Forschung 42(5): 592-594
Zankowska-Jasińska, W.; Borowiec, H.; Kolasa, A.; Ostrowska, K.; Zaleska, B.; Przemyk, B.; Krzywosiński, L.; Bogdal, M.; Kieryłowicz, H. 1990: 1,3-disubstituted 2-thioxo-4,5-imidazolidinediones and 2,4,5-imidazolidinetriones and their anticonvulsant activity Polish Journal of Pharmacology and Pharmacy 42(1): 59-68
Lange, J.; Rump, S.; Ilczuk, I.; Lapszewicz, J.; Rabsztyn, T.; Walczyna, K. 1977: Synthesis and properties of cyclic derivatives of succinic acid with anticonvulsant activity Die Pharmazie 32(10): 579-581
Zankowska-Jasińska, W.; Borowiec, H.; Golus, J.; Kolasa, A.; Zaleska, B.; Krzywosiński, L.; Bogdal, M.; Przemyk, B. 1990: Synthesis and pharmacological investigations of 3-(aminoalkylene)-1-aryl-2-thioxo-4,5-imidazolidinedione and 2,4,5-imidazolidinetrione derivatives Polish Journal of Pharmacology and Pharmacy 42(1): 49-58
Ozkanli, F.; Dalkara, S.; Caliş, U.; Willke, A. 1994: Synthesis of some N-arylazole acetamide derivatives and their anticonvulsant and antimicrobial activities Arzneimittel-Forschung 44(8): 920-924
Caliş, U.; Septioğlu, E.; Aytemir, M.D. 2011: Synthesis and anticonvulsant evaluation of some novel (thio)semicarbazone derivatives of arylalkylimidazole Arzneimittel-Forschung 61(6): 327-334
Kamiński, K.; Obniska, J. 2008: Synthesis and anticonvulsant properties of new 1-(2-pyridinyl)- 3-substituted pyrrolidine-2,5-dione derivatives Acta Poloniae Pharmaceutica 65(4): 457-465
Abdallah, N.A.; el-Shabrawy, O.; el-Eraky, W. 1997: Synthesis of some indane derivatives of central muscle relaxant and anticonvulsant profiles Farmaco 52(12): 733-739
Szilágyi, G.; Kasztreiner, E.; Borsy, J. 1975: Substituted benzyl- and benzoyl carbamide derivatives of anticonvulsant activity Acta Pharmaceutica Hungarica 45(4): 145-154
Pirianowicz-Chaber, E.; Paruszewski, R. 2002: Analytical studies on two amino acid derivatives of anticonvulsant activity Acta Poloniae Pharmaceutica 59(4): 239-241
Pirianowicz-Chaber, E.; Paruszewski, R. 2001: Qualitative and quantitative analysis of new amino acid derivatives of anticonvulsant activity Acta Poloniae Pharmaceutica 58(3): 147-149
Alunni Bistocchi, G.; De Meo, G.; Pedini, M.; Ricci, A.; Bastianini, L.; Sposini, T.; Sbaraglia, G.; Jacquignon, P. 1986: New heterocyclic derivatives of benzimidazole with germicidal activity. III. Synthesis and activity of derivatives of (formyl-5'-furyl-2')-2-benzimidazole with different substitutions at position 5 Il Farmaco; Edizione Scientifica 41(12): 970-983
Gürsoy, A.; Karali, N. 1995: Synthesis and anticonvulsant activity of new acylthiosemicarbazides and thiazolidones Farmaco 50(12): 857-866
Foks, H.; Janowiec, M. 1978: Pyrazine derivatives. XI. Synthesis and tuberculostatic activity of derivatives of pyrazineurea and pyrazinethiourea Acta Poloniae Pharmaceutica 35(5): 615-618
Pancechowska-Ksepko, D.; Foks, H.; Landowska, E.; Janowiec, M.; Zwolska-Kwiek, Z. 1986: Studies of pyrazine derivatives. XVII. Synthesis and the tuberculostatic activity of pyrazinyl-1,3,4-oxadiazole derivatives Acta Poloniae Pharmaceutica 43(2): 116-123
Milczarska, B.; Foks, H.; Trapkowski, Z.; Milzyńska-Kołaczek, A.; Janowiec, M.; Zwolska, Z.; Andrzejczyk, Z. 1998: Studies on pyrazine derivatives. XXXII. Synthesis and tuberculostatic activity of acetylpyrazine thiosemicarbazone derivatives Acta Poloniae Pharmaceutica 55(4): 289-295
Milczarska, B.; Foks, H.; Sokołowska, J.; Janowiec, M.; Zwolska, Z.; Andrzejczyk, Z. 1999: Studies on pyrazine derivatives. XXXIII. Synthesis and tuberculostatic activity of 1-[1-(2-pyrazinyl)-ethyl]-4-N-substituted thiosemicarbazide derivatives Acta Poloniae Pharmaceutica 56(2): 121-126
Rudnicka, W.; Foks, H.; Janowiec, M.; Zwolska-Kwiek, Z. 1986: Studies of pyrazine derivatives. XXI. Synthesis and tuberculostatic activity of 4-aryl-1-pyrazinoylthiosemicarbazides and the products of their cyclization to 1,2,4-triazole-3-thione derivatives Acta Poloniae Pharmaceutica 43(6): 523-528
Ozkirimli, S. 1993: New 2-thioxo-4,5-imidazolidinedione derivatives as possible anticonvulsants Die Pharmazie 48(10): 780