Studies on pyrazine derivatives. XXXIII. Synthesis and tuberculostatic activity of 1-[1- (2-pyrazinyl) -ethyl]-4-N-substituted thiosemicarbazide derivatives
Milczarska, B.; Foks, H.; Sokołowska, J.; Janowiec, M.; Zwolska, Z.; Andrzejczyk, Z.
Acta Poloniae Pharmaceutica 56(2): 121-126
1999
ISSN/ISBN: 0001-6837 PMID: 10635356 Document Number: 499998
Hydrogenation of 4-N-substituted thiosemicarbazonic acid acetylpyrazine derivatives with NaBH4 in dry ethanol led to seventeen new compounds. The in vitro tuberculostatic activity investigations of the 15 synthesized compound were carried out. MIC few of i.v. compounds were lower than 32 micrograms/cm3.
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