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Studies on the quantitative structure-activity relationships in pyrazine carbothioamide derivatives

Kaliszan, R.; Foks, H.; Janowiec, M.

Polish Journal of Pharmacology and Pharmacy 30(4): 579-583

1978

ISSN/ISBN: 0301-0244
PMID: 740560
Document Number: 127916
Quantitative relationships were studied between tuberculostatic potency in vitro and structure parameters of pyrazine carbothioamides. The activity of the compounds was dependent on the parameters related to the size of the substituent and electronic properties of the molecule. An equation was obtained, statistically significant on the 99% level, which described about 71% of variance of activity data for the compounds under study as a function of molar refractivity of the substituent and the wavelength at which absorption maximum occurred.

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