Quantitative structure-activity relationships. Fujita-Ban analysis of beta-adrenergic blocking activity of 1-phenoxy-3- ([ (substituted amido) alkyl]amino) -2-propanols
Gombar, V.
Arzneimittel-Forschung 36(7): 1014-1018
1986
ISSN/ISBN: 0004-4172 PMID: 2876713 Document Number: 277900
Quantitative structure-activity relationship studies have been performed in a series of 81 beta-adrenergic blocking 1-phenoxy-3-([substituted amido)alkyl] amino)-2-propanols using the Fujita-Ban model. A correlation significant at p less than 0.0005 (r = 0.883, F46,34 = 2.60) was obtained using 46 independent substituents. The set of independent substituents has been successfully contracted to 36 substituents (F 36,44 = 4.26). On the basis of the calculated group contributions the derivatives with high predicted activity have been proposed.