Irritation and staining by dithranol (anthralin) and related compounds: II. Structure-activity relationships among 10-meso-substituted acyl analogues
Mustakallio, K.K.
Acta Dermato-Venereologica 60(2): 169-171
1980
ISSN/ISBN: 0001-5555 PMID: 6155030 Document Number: 157654
Irritation and staining by dithranol and some 10-meso-substituted acyl analogues was studied with the chamber-testing technique in a series of 50 psoriasis patients. The test concentrations for dithranol, 10-acetyldithranol, 10-propionyldithranol and 10-butyryldithranol were 0.05 and 0.5%, for 10-valeryldithranol 5% and for 10-myristolydithranol 10%. As a rule, with increasing length of the carbon chain of the 10-acyl substituent (from 2C to 14C) the staining and irritative properties of the molecule decreased.