Structure-anticonvulsant activity relationships of some cinnamamides of substituted aromatic ring
Wang, S.Y.; Li, R.L.; Liu, W.Q.; Wang, G.Q.; Liu, P.; Song, J.M.; Pei, Y.Q.; Yao, H.Y.; Gao, X.M.
Yao Xue Xue Bao 21(7): 542-545
1986
ISSN/ISBN: 0513-4870 PMID: 3811946 Document Number: 285132
Twenty-six compounds of halogen, nitro, alkoxy, amino, and acetamino substituted cinnamamides have been synthesized. The coupling constants of the NMR spectra of the protons on the double bond of these compounds demonstrate that their configurations are all trans. The anticonvulsant activity (MES) of 3-chloro and 2,4-dichloro substituted cinnamamides were found to be more potent than other membranes of the series studied. The anticonvulsant activities of electron donating amino substituted cinnamoyl piperidines are comparable with those of the chloro compounds.