Anticonvulsant activity of p-chlorophenyl substituted arylsemicarbazones--the role of primary terminal amino group
Pandeya, S.N.; Mishra, V.; Ponnilavarasan, I.; Stables, J.P.
Polish Journal of Pharmacology 52(4): 283-290
2000
ISSN/ISBN: 1230-6002 PMID: 11345484 Document Number: 516450
A series of p-chlorophenyl substituted arylsemicarbazones were synthesized and evaluated for anticonvulsant activity. Most of the compounds provided significant protection against maximal electroshock-induced seizures (MES) at 100 mg/kg after 0.5 h and at 300 mg/kg after 4 h in both MES and pentetrazole-induced (PTZ) seizures. In the strychnine-induced seizures (scSTY), the majority of the compounds showed protection at 30 mg/kg. The compound 2 was active in both MES and PTZ tests. The study has shown that the terminal primary amino group is not necessary for anticonvulsant activity.