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Synthesis, characterization and anticonvulsant activity evaluation of some 1,4-dihydropyridines and 3,5- (substituted) oxycarbonyl-1,4-dihydro-2,6-dimethyl-N-[2- (4-sulfamoylphenylamino) -acetyl]-4- (substituted) pyridines

Subudhi, B.B.; Panda, P.K.; Swain, S.P.; Sarangi, P.

Acta Poloniae Pharmaceutica 66(2): 147-153

2009

ISSN/ISBN: 0001-6837
PMID: 19719048
Document Number: 637774
A series of 3,5-(substituted)oxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(substituted)pyridines (1a-j) were synthesized by Hantzsch method for pyridine synthesis. Treatment with chloroacetyl chloride produced N-(2-chloroacetyl)-3,5-(substituted)oxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(substituted)pyridines (2a-e), which on further treatment with sulfanilamide resulted in 3,5-(substituted)oxycarbonyl-1,4-dihydro-2,6-dimethyl-N-[2-(4-sulfamoylphenylamino)-acetyl]-4-(substituted)pyridines (3a-e). The structures has been established on the basis of spectral (IR, 1H-NMR, mass) and elemental analysis. Compounds 1a-j and 3a-e (5 mg/kg and 10 mg/kg) were evaluated for their anticonvulsant effect against pentylenetetrazole-induced convulsions with diazepam (4 mg/kg) as the reference. Compounds 3a-e exhibited significant (p<0.01) anticonvulsant activity compared to the control.

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