Synthesis and antibacterial activity of 7-substituted-1-ethyl (2-fluoro-ethyl) -6,8-difluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid
Yan, L.; Xu, B.; Ma, Z.; Zhu, Y.; Yang, Q.
Yao Xue Xue Bao 33(5): 392-395
1998
ISSN/ISBN: 0513-4870 PMID: 12017009 Document Number: 488028
Eighteen 7-substituted-1-ethyl (2-fluoroethyl)-6, 8-difluoro-1, 4-dihydro-4-oxoquinolone-3-carboxylic acid were designed and synthesized. The results of preliminary antibacterial test showed that most of the compounds exhibited definite activities in test against pathogenic bacteria. Especially, compound 17 and 18 showed better activities and surpassed fleroxacin when compared in vitro.
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