Synthesis and antibacterial activities of 1-amino-6-fluoro-1,4-dihydro-4-oxo-7- (substituted) piperazinyl-3-quinolinecarboxylic acids and their derivatives
Xin, T.; Ding, J.; Zhang, X.P.
Yao Xue Xue Bao 28(11): 865-869
1993
ISSN/ISBN: 0513-4870 PMID: 8010004 Document Number: 419129
The title compounds 6 apprx 24 were obtained by the reaction of 5 with corresponding benzaldehydes. 5 was prepared with ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate by hydrolysis, amination and condensation with piperazine. Anti-bacterical activities of 5 apprx 24 were tested in vitro.
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