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Synthesis, physicochemical and anticonvulsant properties of some n-substituted amides of 3-spirocycloalkylpyrrolidine-2,5-dione

Obniska, J.; Zejc, A.

Acta Poloniae Pharmaceutica 60(5): 383-390

2003

ISSN/ISBN: 0001-6837
PMID: 15005422
Document Number: 556528
The synthesis and physicochemical properties of new derivatives of N-benzyl and N-phenyl amides of 2-(3-spirocyclohexanepyrrolidine-2,5-dione) acetic acid. 4-(3-spirocyclohexanepyrrolidine-2,5-dione) benzoic acid and 4-(3-spirocyclopentanepyrrolidine-2,5-dione) benzoic acid are described. N-substituted amides were prepared by condensing the obtained acids with the corresponding phenyl- or benzylamine derivatives in DMF, in the presence of the N,N-carbonyldiimidazol (CDIM) reagent at room temperature. The compounds were evaluated for anticonvulsant activity. The portion coefficients were calculated using the Prolog P module of the Pallas system. The structure of the new amides was confirmed by elemental and spectral analyses.

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