Synthesis and pharmacological properties of some 2-substituted 1- (3-pyridyl) -1,2,3,4-tetrahydro-beta-carbolines
Misztal, S.; Boksa, J.; Chojnacka-Wójcik, E.; Tatarczyńska, E.; Lewandowska, A.
Polish Journal of Pharmacology and Pharmacy 39(1): 97-103
1987
ISSN/ISBN: 0301-0244 PMID: 3499603 Document Number: 288808
Six derivatives of 2-aminoacetyl-1,2,3,4-tetrahydro-beta-carboline (2a-f) were obtained, which yielded as a result of reduction with LiAlH4 six respective 2-aminoethyl-derivatives (3a-f). Pharmacological studies revealed that compounds 2f, 3e and 3f have sedative properties. None of the compounds possesses neuroleptic, antidepressive, anxiolytic, analgesic or anticonvulsant properties.
Document emailed within 1 workday
Related Documents
Nawrocka, W.; Rutkowska, M.; Szelag, A.; Barczyńska, J.; Kedzierska-Goździk, L.; Błaszczyk, F.; Dziwiszek, W. 1996: Synthesis and pharmacological properties of new derivatives of 4-methyl-5-oxalo-1H-2,3,4,5-tetrahydro-1,5-benzodiazepin-2-one and beta-oxo-5-(4-methyl-1H-2,3,4,5-tetrahydro-1,5-benzodiazepin-2 -one)propionic acid Acta Poloniae Pharmaceutica 53(6): 425-430Gaignault, J.C.; Fréchet, D.; Nédelec, L. 1978: 1-(indolymethyl) 2,3,4,9-tetrahydro-1H-beta-carbolines prepared from tryptamine or from its derivatives Annales Pharmaceutiques Francaises 36(11-12): 561-568
Buckholtz, N.S. 1982: Interaction of tetrahydro-beta-carbolines with brain serotonin metabolism Progress in Clinical and Biological Research 90: 183-190
Beck, O.; Bosin, T.R.; Holmstedt, B.; Lundman, A. 1982: A GC-MS study on the occurrence of two tetrahydro-beta-carbolines implicated in alcoholism Progress in Clinical and Biological Research 90: 29-40
Bosin, T.R. 1985: A simple, sensitive procedure for the determination of tetrahydro-beta-carbolines and their precursors Progress in Clinical and Biological Research 183: 179-188
Delarge, J. 1976: Synthesis and pharmacological properties of some N-acyl pyridine-3-sulfonamides substituted at position 2 Acta Poloniae Pharmaceutica 33(1): 1-6
Brancaccio, G.; Lettieri, G.; Monforte, P.; Larizza, A. 1982: Synthesis and pharmacological properties of some 2-substituted dibenz[2,3:6,7]-3a,12b-dihydrooxepin[4,5-d]1,3-dioxolane derivatives Il Farmaco; Edizione Scientifica 37(11): 711-718
Graczyk, J.; Kamińska, A.; Szadowska, A.; Tkaczyński, T.; Urbańska, A. 1976: Synthesis and pharmacological properties of some new diphenylacetic acid amides substituted at the nitrogen atom Acta Poloniae Pharmaceutica 33(5): 585-592
Boksa, J.; Charakchieva-Minol, S.; Duszyńska, B.; Bugno, R.; Kłodzińska, A.; Tatarczyńska, E.; Chojnacka-Wójcik, E.; Bojarski, A.J. 2003: Synthesis, in vitro and in vivo 5-HT1A/5-HT2A serotonin receptor activity of new hybrid 1,2,3,4-tetrahydro-gamma-carbolines with 1-(2-methoxyphenyl)piperazine moiety Polish Journal of Pharmacology 55(6): 1013-1019
Mokrosz, J.L.; Dukat, M.; Misztal, S.; Chojnacka-Wójcik, E.; Tatarczyńska, E. 1990: Structure-activity relationship studies of CNS agents. Part 1: the Free-Wilson analysis of acute toxicity and sedative effect of some 1,2,3,4-tetrahydro-beta-carbolines Die Pharmazie 45(10): 765-767
Vega, S.; Gil, M.S.; Darias, V.; Sanchez Mateo, C.C.; Exposito, M.A. 1995: Synthesis and pharmacological study of 5,6,8,9-tetrahydro-4H, 7H-pyrrolo[1,2-a]cyclopenta[b]thieno[3,2-f][1,4]diazepines Die Pharmazie 50(1): 27-33
Caliari, S.; Alfieri, L.; Gervasi, G.B.; Sangiovanni, M.P.; Scrollini, F. 1977: Pharmacological properties of the anti-inflammatory agent pyridyl-biphenylyl-acetamide (diphenpyramide) Arzneimittel-Forschung 27(11): 2086-2093
Ponticelli, F.; Pagani, R.; Missale, M.C.; Leoncini, R.; Vannoni, D.; Marinello, E. 1983: Synthesis and NMR properties of 2-(4-pyridyl) thiazolidine-4-carboxylic acids Italian Journal of Biochemistry 32(2): 92-101
Bonacchi, G.; Agostini, O.; Fedi, M.; Bacciarelli, C.; Boni, P.; Castellucci, A.; Perretti, F.; Manzini, S. 1988: Resolution and pharmacological properties of the enantiomers of the potent alpha-adrenoceptor antagonist 1-[2-ethoxy-2-(3'-pyridyl)ethyl]-4-(2'-methoxy-phenyl)piperazine Arzneimittel-Forschung 38(5): 650-654
Pawłowski, M.; Drabczyńska, A.; Gorczyca, M.; Malec, D.; Modzelewski, J. 1994: Synthesis and pharmacological screening of novel 10-substituted diazepino-[2,1-f]-purines Acta Poloniae Pharmaceutica 51(4-5): 385-391
Chernikh, V.P.; Petiunin, G.P.; Krasnovskaia, O.O. 1972: Synthesis and pharmacological activity of substituted amides of pyridinecarboxylic acids Farmatsevtychnyi Zhurnal 27(1): 16-18
Gutkowska, B.; Wasiak, J. 1984: Synthesis of various 5,5-substituted derivatives of 3-dialkylamino-alkylohydantoin with potential pharmacological activity Acta Poloniae Pharmaceutica 41(3): 307-311
Sieroslawska, J.; Hano, J.; Sypniewska, M.; Czarnedki, R.; Chojnacka-Wójcik, E.; Harasiewicz, A. 1974: Pharmacological properties of substituted gamma-butyrolactones. Part II. Antoconvulsant action Polish Journal of Pharmacology and Pharmacy 26(6): 516-525
Zabska, R.; Jakóbiec, T.; Dobek, R.; Wilimowski, M.; Barczyńska, J.; Kedzierska-Goździk, L.; Wojewódzki, W.; Rutkowska, M.; Duś, E.; Szelag, A. 1991: Synthesis and pharmacological properties of derivatives of alpha-amino-beta-(p-chlorobenzoyl)-propionic acid and alpha-amino-gamma-(p-chlorophenyl)-tetrahydrofuran-2-one Polish Journal of Pharmacology and Pharmacy 43(4): 271-280
Turło, J.; Zawadowski, T.; Rump, S.; Jakowicz, I.; Gidyńska, T.; Gałecka, E. 1994: Synthesis and pharmacological screening of some N,N'-bis-[4-(4-aryl-1-piperazinyl)butyl]-substituted derivatives of 1,8-dimethylbicyclo-[2.2.2]oct-7-ene-2,3,5,6-tetracarboxydiimide Polish Journal of Pharmacology 46(5): 451-455