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Synthesis and pharmacological properties of derivatives of alpha-amino-beta- (p-chlorobenzoyl) -propionic acid and alpha-amino-gamma- (p-chlorophenyl) -tetrahydrofuran-2-one

Zabska, R.; Jakóbiec, T.; Dobek, R.; Wilimowski, M.; Barczyńska, J.; Kedzierska-Goździk, L.; Wojewódzki, W.; Rutkowska, M.; Duś, E.; Szelag, A.

Polish Journal of Pharmacology and Pharmacy 43(4): 271-280

1991

ISSN/ISBN: 0301-0244
PMID: 1811219
Document Number: 380384
Several new alpha-aminoderivatives of gamma-(p-chlorophenyl)-tetrahydrofuran-2-one were synthesized. alpha-Aminoderivatives of beta-(p-chlorobenzoyl)-propionic acid 2-13 were used as the substrates. After the reduction with NaBH4 at 10-12 degrees C and cyclization the compounds were converted into the appropriate derivatives of tetrahydrofuran-2-one 16-26. In pharmacological tests compounds 9 and 26 abolished the aggressiveness in isolated mice while compound 8 showed antiinflammatory activity.

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