Reaction of N,N-disubstituted alpha-aminomethyleneketones with tosyl isocyanate. Synthesis of amino-disubstituted 2-acyl-3-amino-N-tosylpropenamides, N,N- (3-amino-1-alkyl-2-propenylidene) and N,N-[2- (aminomethylene) cyclohexylidene]tosylamides

Romussi, G.; Parodi, B.; Bignardi, G.; Menozzi, G.; Schenone, P.

Il Farmaco; Edizione Scientifica 41(7): 539-547

1986


ISSN/ISBN: 0430-0920
PMID: 3743747
Document Number: 277004
The reaction of N,N-disubstituted open-chain and cyclohexane alpha-aminomethyleneketones (I) and (II) with p-toluenesulfonyl (tosyl) isocyanate gave amino-disubstituted 2-acyl-3-amino-N-tosylpropenamides (III) and/or N,N-(3-amino-1-alkyl-2-propenylidene) and N,N-[2-(aminomethylene)-cyclohexylidene] tosylamides (IV) and (V), the final product being related to the carbon and nitrogen substituents of the enaminone. The evaluation of the hypoglycemic activity concerning some of the above compounds gave no interesting results.

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