Synthesis of modified peptides with C-terminal alpha-amino aldehydes
Potetinova, Z.V.; Mil'gotina, E.I.; Makarov, V.A.; Voiushina, T.L.
Bioorganicheskaia Khimiia 27(3): 163-173
2001
ISSN/ISBN: 0132-3423 PMID: 11443937 Document Number: 528952
Various synthetic approaches to modified peptides with the C-terminal aldehyde group, capable of inhibiting a number of proteolytic enzymes belonging to the classes of thiol, serine, and aspartyl proteases, are considered. Both chemical methods, including solid phase peptide synthesis now widely used, and biocatalytic synthetic methods for obtaining these substances are discussed in detail.
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