Structure-activity relationship studies of CNS agents. Part 1: the Free-Wilson analysis of acute toxicity and sedative effect of some 1,2,3,4-tetrahydro-beta-carbolines
Mokrosz, J.L.; Dukat, M.; Misztal, S.; Chojnacka-Wójcik, E.; Tatarczyńska, E.
Die Pharmazie 45(10): 765-767
1990
ISSN/ISBN: 0031-7144 PMID: 2089388 Document Number: 353587
It has been found that 3-alkoxycarbonyl-beta-carbolines are almost non-toxic and showed a sedative effect. The quantitative relationship between the structure of some 1,2,3,4-tetrahydro-beta-carbolines and their acute toxicity and sedative effect was found using the Free-Wilson approach.
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