Quantitative analysis of structure-activity relationship in the acridine series. Part 2: Antitumor 9-thiadiazolo-acridine derivatives
Mrozek, A.; Karolak-Wojciechowska, J.; Amiel, P.; Barbe, J.
Acta Poloniae Pharmaceutica 57(6): 425-430
2000
ISSN/ISBN: 0001-6837 PMID: 11243248 Document Number: 516821
Synthesis and activity, vs. leukaemia cells of new 9-thiadiazolo acridine derivatives are reported. In addition, electronic properties and molecular structure are correlated with biological activity of these molecules. Results are in agreement with the capability of drugs to intercalate into DNA.
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