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Quantitative "structure-antimicrobial activity" relations of the new azole derivatives

Patratiĭ, V.K.; Sinchenko, V.G.; Prodanchuk, N.G.; Butkovskiĭ, I.V.; Drach, B.S.

Mikrobiolohichnyi Zhurnal 51(3): 48-52

1989

ISSN/ISBN: 0201-8462
PMID: 2796787
Document Number: 330172
New azole derivatives are synthesized and examined with the purpose of searching antimicrobic drugs and of determining the quantitative structure--activity relationships. Their antifungal and antibacterial activity is fixed. Certain regularities of the relationships between the chemical structure of compounds and their activity are determined by the Free-Wilson model. The influence of aryl and alkyl radicals in 1.2 and 5 positions of azoles on antimicrobial properties is discussed. Prospects for the further studies of this group of chemicals are shown.

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