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Relation between Chemical Structure and Antimicrobial Action. 4. Studies on the Fungistatic Properties of some 5-Nitrofuraldehyde Derivatives

Tartler, G.; Weuffen, W.; Herrmann, B.

Die Pharmazie 18: 495-496

1963

ISSN/ISBN: 0031-7144
PMID: 14052372
Document Number: 9772
Es wurden verschiedene 5- Nitro-furaldehyd-Derivate auf ihre wachstumshemmenden Eigenschaften gegen Dermatophyten und pathogene Hefen getestet. Das N-(5-Nitro-furfuryliden)-2-amino-thiazol und das 5-Nitro-2-furaldehyd-diacetat hatten in höheren Verdünnungen gute wachstumshemmende Eigenschaften auf Pilze. Das 5-Nitro-furaldehyd-isonicotinsäurehydrazon, das kaum wirksam war, wenn es in einer Natriumchloridverreibung dem Nährboden zugesetzt wurde, zeigte in Triäthanolaminlösung einen sehr guten Effekt. Weitere Verbindungen führten bis in hohe Verdünnungen zu einer Herabsetzung des Pilzwachstums. Eine absolute Wachstumshemmung wurde aber erst in starken Konzentrationen erreicht.

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Relation between Chemical Structure and Antimicrobial Action. 4. Studies on the Fungistatic Properties of some 5-Nitrofuraldehyde Derivatives

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