3,3'-bi-1,3-thiazolidine]-4,4'-dione system. III. Evaluation of the antimicrobial and antitumor properties of 2,2'-disubstituted derivatives and their 1,1'-disulfones
Basile, M.; Previtera, T.; Vigorita, M.G.; Fenech, G.; Pizzimenti, F.C.
Il Farmaco; Edizione Scientifica 41(8): 637-643
1986
ISSN/ISBN: 0430-0920 PMID: 3743754 Document Number: 270596
A series of dl and meso 2,2'-disubstituted-[3,3'-bis-1,3-thiazolidine]-4,4'-diones and their 1,1'-disulfone derivatives have been tested for their antimicrobial activity against gram-positive, gram-negative and Candida strains and for antitumor activity against leukemic P.388 tumor system in mice. None of the tested bi-thiazolidinones showed any significant antitumor properties; only few 1,1'-disulfones exhibited some antibacterial activity.