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Design, Synthesis and Biological Evaluation of 2,3-Disubstituted and Fused Quinoxalines as Potential Anticancer and Antimicrobial Agents

Abbas, H.-A.S.; Al-Marhabi, A.R.M.; Ammar, Y.A.

Acta Poloniae Pharmaceutica 74(2): 445-458

2017

ISSN/ISBN: 0001-6837
PMID: 29624250
Document Number: 693249
This article describes the synthesis of new bioactive quinoxalines as potential anticancer and antimicrobial agents; 2,3-dichloroquinoxaline was used as the key molecule for the preparation of various mono or disubstituted quinoxalines 2-7, pyridoimidazoquinoxaline derivative 8, thiazolo[4,5-b]quinoxaline derivatives 9-11, piperazinoquinoxaline derivatives 12, 13 and 1,4-benzoxazino[2,3-b]quinoxaline 15. The newly synthesized compounds were evaluated for their anticancer and antimicrobial activity. Assay results showed the compounds 6-bromo-2-chloro-N-[4-(trifluoromethyl)phenyl]-3-aminoquinoxaline (4), 7-bromo-2-[2-(4-methoxy-benzylidene) hydrazinyl]thiazolo[5,4-b]quinoxaline (9d) and 7-bromo-1,2,3,4-tetrahydropyrazino[2,3- blquinoxaline (12) proved to possess dual effects as potential anti-cancer and antimicrobial agents.

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