Synthesis, biological evaluation and molecular docking of aryl hydrazines and hydrazides for anticancer activity
Gohil, V.M.; Agrawal, S.K.; Saxena, A.K.; Garg, D.; Gopimohan, C.; Bhutani, K.K.
Indian Journal of Experimental Biology 48(3): 265-268
2010
ISSN/ISBN: 0019-5189 PMID: 21046979 Document Number: 639213
Aryl hydrazine and hydrazide analogues were synthesized based on p-tolyl hydrazine, isolated as a breakdown product of a secondary metabolite from the mushroom, Agaricus bisporus, and tested to be highly active molecule than 5-fluorouracil in in vitro anticancer studies. The synthesized analogues were tested for anticancer activity using NCI protocol. Anolgues 12 and 15 emerged as molecules with significant in vitro anticancer activity. Molecular docking study revealed the binding orientations of aryl hydrazines and hydrazides analogues in the active sites of thymidylate synthase.