Synthesis of 1.4-naphthoquinones-4-aryl (aroyl) hydrazones of potential antimicrobial activity
Roushdi, I.M.; Ibrahim, E.S.; Habib, N.S.
Die Pharmazie 31(12): 856-859
1976
ISSN/ISBN: 0031-7144 PMID: 1023262 Document Number: 101608
The isolation of phthiocol (3-hydroxy-2-methyl-1.4-naphthoquinone) from the acetone-soluble fat fraction of tubercle bacilli [1, 2] and the confirmation that it had antituberculous activity against H-37 R.V. strain [20] in vitro and in mice [12], prompted the synthesis of some 2-alkyl-3-hydroxy-1.4-naphthoquinone-4-aryl(aroyl)hydrazones as possible tuberculostatic agents.
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