Synthesis and antimicrobial properties of new aroyl-acrylic esters of polyethylene glycols
Dal Pozzo, A.; Acquasaliente, M.; Donzelli, G.; Delor, F.; Ferruti, P.
Il Farmaco; Edizione Scientifica 41(8): 622-629
1986
ISSN/ISBN: 0430-0920 PMID: 3743753 Document Number: 284141
Eight new aroyl-acrylic esters of polyethylene glycols were prepared using different synthetic ways. They are supposed to possess a higher activity as antimicotic agents for topical use, by favouring skin adsorption. Except in few cases, the antimicrobial activity of the oligomeric derivatives resulted generally decreased in vitro, in comparison to simple alkyl esters previously prepared. However, only pharmacological screenings for antimicotic activity in vivo will give a definite response on whether the new derivatives are advantageous for topical use.