Polyethylene glycols. Studies of absorption, excretion, retention, and identification
Principe, A.H.
Journal of Forensic Sciences 13(1): 90-113
1968
ISSN/ISBN: 0022-1198 PMID: 5644891 Document Number: 3163
1. Twenty-nine hours, plus or minus 30 minutes, after a maximum intravenous dosage of PEG 400, no horse tested positive for polyethylene glycols. 2. PEG 400 and PEG 4000 are not measurably absorbed through the skin and excreted in the urine after topical application to normal skin or after topical application to incised areas of skin. 3. After two oral doses of 4,258 mg of PEG 4000, the average recovery in urine was 1.07% during 72 hours. Significantly, no urine sample tested chemically positive, eliminating oral administration as the route of entry of chemically detectable PEG 4000 in urine. 4. PEG 4000 is readily excreted and recovered from the urine after intramuscular injections. After intramuscular injection of 1,216 mg, the first negative urine was obtained after 29 hours, 30 minutes. At this time 99.7% of the recoverable PEG 4000 had been excreted. 5. Subcutaneously injected PEG 4000 is also excreted, but at a slightly slower rate, the first negative urine appearing 33 hours, 55 minutes after administration. Within this time interval 99.4% of the recoverable PEG 4000 had been excreted in the urine. 6. Gel permeation chromatography is useful in the identification of average molecular weights of polyethylene glycol polymers.
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