Top Abstract Purchase Related
Home
>
Node
>
Subnode

Synthesis and antimicrobial properties of substituted 3-aminoxypropionyl and 3-aminoxy- (E) -2-methoxyiminopropionyl monobactams

Balsamo, A.; Macchia, B.; Orlandini, E.; Rossello, A.; Macchia, F.; Broccali, G.; Fonio, W.

Farmaco 45(7-8): 879-888

1990

ISSN/ISBN: 0014-827X
PMID: 2282121
Document Number: 362084
The substituted 3-aminoxypropionyl (VII) and 3-aminoxy-(E)-2-methoxyiminopropionyl monobactams (VIII) which possess the monocyclic .beta.-lactam nucleus of aztreonam (IX) were synthesized by reaction of triethylammonium (3S, 4S)-3-amino-4-methyl-2-oxo-1-azetidinsulfonate with the aminoxy acids X and XI, respectively. Compounds VII and VIII were assayed in vitro for their antimicrobial properties against Gram-positive and Gram-negative bacteria, whether producers of .beta.-lactamases or otherwise. Both types of compounds (VII and VIII) exhibited a poor antibacterial activity towards Gram-positive bacteria, comparable to that of aztreonam. On the contrary VII and VIII proved to be practically inactive against Gram-negative microorganisms, towards which aztreonam exhibits a high degree of activity.

Document emailed within 1 workday
Secure & encrypted payments

Ersan, S.; Nacak, S.; Acar, N.; Noyanalpan, N. 1997: Synthesis and antimicrobial activity of 1-dialkylaminomethyl- 2-(p-substituted phenyl)-5-substituted benzimidazole derivatives Arzneimittel-Forschung 47(4): 410-412
Goes, A.J.; De Lima, M.C.; Galdino, S.L.; Pitta, I.R.; Luu-Duc, C. 1991: Synthesis and antimicrobial activity of substituted fluorobenzyl benzylidenethiazolidinediones and imidazolidinediones Journal de Pharmacie de Belgique 46(4): 236-240
Farghaly, A.M.; Mohsen, A.; Omar, M.E.; Khalil, M.A.; Gaber, M.A. 1990: Synthesis of 3-aryl-2-substituted-4(3H)-quinazolines as potential antimicrobial agents Farmaco 45(4): 431-438
Charles, E.S.; Rao, K.V.; Sharma, S. 1982: Synthesis of substituted benzamides and benzimidazoles as anthelmintic and antimicrobial agents Die Pharmazie 37(6): 413-415
el-Shaaer, H.M.; Abdel-Aziz, S.A.; Allimony, H.A.; Ali, U.F.; Abdel-Rahman, R.M. 1997: Synthesis and antimicrobial activities of some new 2-substituted benzoxazole/benzothiazole derivatives Die Pharmazie 52(8): 585-589
Bhat, M.A.; Al-Omar, M.A.; Siddiqui, N. 2011: Synthesis of 2-(substituted phenyl)-3-[5-(2-oxo-2H-chromen-3-yl)-1,3,4-oxadiazol-2-yl]-1,3-thiazolidin-4-ones with antimicrobial activity Acta Poloniae Pharmaceutica 68(2): 295-299
Fayed, A.A.; Amr, A.E.-G.E.; Al-Omar, M.A.; Mostafa, E.E. 2014: Synthesis and antimicrobial activity of some new substituted pyrido[3',2':4,5]thieno[3,2-d]-pyrimidinone derivatives Bioorganicheskaia Khimiia 40(3): 335-340
Ates, O.; Salman, A.; Cesur, N.; Otük, G. 1993: Synthesis and in vitro antimicrobial activities of some 4-acetylantipyrine N2-(3-substituted-4-phenylthiazoline-2-ylidene)hydrazone derivatives Die Pharmazie 48(2): 143-144
Thunus, L. 1977: Synthesis and pharmacologic properties of various isopropyl and 2,5-substituted hydroxyethylpiperazinylpyridines Annales Pharmaceutiques Francaises 35(5-6): 197-204
Brancaccio, G.; Lettieri, G.; Monforte, P.; Larizza, A. 1982: Synthesis and pharmacological properties of some 2-substituted dibenz[2,3:6,7]-3a,12b-dihydrooxepin[4,5-d]1,3-dioxolane derivatives Il Farmaco; Edizione Scientifica 37(11): 711-718
Obniska, J.; Zejc, A. 2003: Synthesis, physicochemical and anticonvulsant properties of some n-substituted amides of 3-spirocycloalkylpyrrolidine-2,5-dione Acta Poloniae Pharmaceutica 60(5): 383-390
Delarge, J. 1976: Synthesis and pharmacological properties of some N-acyl pyridine-3-sulfonamides substituted at position 2 Acta Poloniae Pharmaceutica 33(1): 1-6
Kamiński, K.; Obniska, J. 2008: Synthesis and anticonvulsant properties of new 1-(2-pyridinyl)- 3-substituted pyrrolidine-2,5-dione derivatives Acta Poloniae Pharmaceutica 65(4): 457-465
Misztal, S.; Boksa, J.; Chojnacka-Wójcik, E.; Tatarczyńska, E.; Lewandowska, A. 1987: Synthesis and pharmacological properties of some 2-substituted 1-(3-pyridyl)-1,2,3,4-tetrahydro-beta-carbolines Polish Journal of Pharmacology and Pharmacy 39(1): 97-103
Graczyk, J.; Kamińska, A.; Szadowska, A.; Tkaczyński, T.; Urbańska, A. 1976: Synthesis and pharmacological properties of some new diphenylacetic acid amides substituted at the nitrogen atom Acta Poloniae Pharmaceutica 33(5): 585-592
Mavel, S.; Rubat, C.; Coudert, P.; Privat, A.M.; Couquelet, J.; Tronche, P.; Bastide, P. 1993: Synthesis of new 5-substituted pyrazolo[1,5-d][1,2,4]-triazine derivatives and their analgesic, anti-inflammatory and antipyretic properties Arzneimittel-Forschung 43(4): 464-468
Shams el-Dine, S.A.; Soliman, F.S.; Ashour, F.A.; Saudi, M.N. 2001: Reactions with pyrrolidine-2,4-diones, Part 4: Synthesis of some 3-substituted 1,5-diphenylpyrrolidine-2,4-diones as potential antimicrobial, anti-HIV-1 and antineoplastic agents Die Pharmazie 56(12): 933-937
Kulikowski, T.; Zawadzki, Z.; Shugar, D.; De Clercq, E. 1981: Pyrimidine arabinofuranosyl nucleosides with 5-substituted long, branched and unsaturated chains: synthesis and antiherpes properties Nucleic Acids Symposium Series 9: 103-106
Dal Pozzo, A.; Acquasaliente, M.; Donzelli, G.; Delor, F.; Ferruti, P. 1986: Synthesis and antimicrobial properties of new aroyl-acrylic esters of polyethylene glycols Il Farmaco; Edizione Scientifica 41(8): 622-629
Pirog, T.R.; Savenko, L.V.; Shevchuk, T.A. 2016: Effect of Zn²⁺ on Synthesis Ofacinetobacter Calcoaceticus Imv B-7241 Surfactants with Antimicrobial and Antiadhesive Properties Mikrobiolohichnyi Zhurnal 78(4): 48-58