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Novel thiazolidine-2,4-dione-4-thiosemicarbazone and 4-[ (3,4-diaryl-3H-thiazol-2-yl) azo]thiazolidin-2-one derivatives: synthesis and evaluation for antimicrobial and anticancer properties

Mohsen, A.; Omar, M.E.; Salama, H.M.; Eshba, N.H.

Il Farmaco; Edizione Scientifica 40(1): 49-57

1985

ISSN/ISBN: 0430-0920
PMID: 3884369
Document Number: 245619
Two novel series of 3-benzylthiazolidine-2,4-dione-4-thiosemicarbazones (V - IX) and 3-benzyl-4-[(3,4-diaryl-3H-thiazol-2-yl)azo]thiazolidin-2-on es (X - XXII) were synthesized as potential antimicrobial and anticancer agents. The products were found to be inactive against a variety of microorganisms and the preliminary antileukemic evaluation of some representative compounds against P 388 lymphocytic leukemia indicated insignificant activity.

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